New Study Links Nanoparticles and Autoimmune Diseases

| June 12, 2012 | 0 Comments More

New research by scientists at Trinity College in Dublin maintains that exposure to nanoparticles, commonly used in sunscreen, cosmetics and other personal care products can have a serious impact on health, linking it specifically to rheumatoid arthritis and the development of other serious autoimmune diseases. We skin sufferers have for a long time been wary of any chemicals but this just high lights the possibility that our flare ups can be caused by the cosmetics and other products we use.

Titanium dioxide (TiO2) nanoparticles, found in everything from cosmetics to sunscreen to vitamins, have already been found to cause systemic genetic damage in mice, according to an earlier comprehensive study conducted by researchers at UCLA’s Jonsson Comprehensive Cancer Center. The TiO2 nanoparticles induced single- and double-strand DNA breaks and also caused chromosomal damage as well as inflammation, all of which increase the risk for cancer. In the Dublin study, the scientists applied a wide range of nanomaterials of different sizes to human cells derived from the lining of the airway passages, and to the cells of so-called phagocytic origin — those cells that are most frequently exposed to the inhaled foreign particles or are tasked with cleaning up our body from them. At the same time, collaborating researchers from the Health Effects Laboratory Division, National Institute for Occupational Safety & Health (Morgantown, WV, USA) have conducted the studies in mice exposed to chronic inhalation of air contaminated with single walled carbon nanotubes.

The result was clear and convincing: all types of nanoparticles in both studies were causing an identical response in human cells and in the lungs of mice, manifesting in the specific transformation of the amino acid arginine into the molecule called citrulline which can lead to the development of autoimmune conditions such as rheumatoid arthritis. In the transformation to citrulline, human proteins which incorporate this modified amino acid as building blocks, can no longer function properly and are subject to destruction and elimination by the bodily defence system. Once programmed to get rid of citrullinated proteins, the immune system can start attacking its own tissues and organs, thereby causing the autoimmune processes which may result in rheumatoid arthritis.

Diseases associated with inhaled nanoparticles include asthma, bronchitis, emphysema, lung cancer, and neurodegenerative diseases, such as Parkinson’s and Alzheimer’s diseases. Nanoparticles in the gastrointestinal tract have been linked to Crohn’s disease and colon cancer. Nanoparticles that enter the circulatory system are implicated in arteriosclerosis, blood clots, arrhythmia, heart diseases, and ultimately death from heart disease. Nanoparticles entering other organs, such as liver, spleen, etc., may lead to diseases of these organs. Some nanoparticles are associated with autoimmune diseases, such as systemic lupus erythematosus, scleroderma, and rheumatoid arthritis.

Link to full article: http://preventdisease.com/news/12/061112_Groundbreaking-Research-Shows-How-Nanoparticles-Are-Causing-Autoimmune-Diseases.shtml?utm_source=061112&utm_campaign=061112&utm_medium=email

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Category: Lichen Sclerosus (LS), Psoriasis

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